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| Tip
of the Month: Using the Chrom Filter |
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To improve the
quality and reproducibility of chromatographic peaks, set the
Chrom Filter value in the Instrument Setup method to the width
of the LC peak, in seconds, at 25% relative abundance. |
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| Quantum Waves: Zero
Cross-Talk |
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| In assays
involving closely eluting multi-target analytes, Selective
Reaction Monitoring (SRM) is the most commonly used mass
spectrometry technique for performing quantitative assays on
triple quadrupole systems. Examples include DMPK assays,
monitoring for drugs of abuse in urine extracts, and pesticide
residues monitoring in environmental samples. The SRM
experiment consists of three distinct events. First, precursor
ions of a specific mass to charge (m/z) ratio are transmitted
through the first quadrupole, while all ions of different m/z
values are filtered out. Secondly, the selected ions... |
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| Download Full
Article (PDF 216 kB) |
| LTQ
Orbitrap™ Webinar
Recording |
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Speaker:
Helmut Muenster, Ph.D.
Agenda: The webinar
introduces the LTQ Orbitrap followed by an explanation of the
geometry of the hybrid instrument. This is followed by a
discussion of specifications and performance highlights. The
webinar concludes with some examples for drug-discovery and
bottom-up proteomics.
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| View Recording
Now |
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| Proteomicsⁿ Resource Library |
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| The Proteomics Resource
Library contains poster presentations from ABRF 2005,
technical presentations, application notes and references for
Finnigan™ LTQ, Finnigan
ProteomeX™ LTQ, Finnigan
LTQ FT™ and Finnigan
vMALDI™. |
| Order your copy
today! |
| Thermo at HUPO
2005 |
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| Thermo's Proteomicsⁿ workshop at HUPO 2005 will cover solutions
for high-throughput protein identification, PTM
characterization, top-down analysis, and biomarker discovery.
A high-level summary will be followed by detailed
presentations describing the use of Thermo mass spectrometers
by two important contributors to the Human Proteome Project,
namely, Professors Chris Turck and Matthias Mann, both from
the Max Planck Institute. |
| More
Information |
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| Thermo's ASMS 2005
CD |
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The 2005 ASMS CD contains
posters and presentations from Thermo covering top-down
proteomics, biomarker discovery, small molecule quantitation,
bioanalysis, metabolomics, etc.
|
| Order your copy
today! |
| Clinical Proteomics
Workshop |
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| The Clinical Proteomics
Workshop at Vanderbilt University will be held from September
26 - 30 2005. This four day workshop is for basic and clinical
scientists interested in applying proteomics methods to
translational and clinical research. Topics covered include
analytical technologies, informatics tools and proteomics
approaches to biomarker discovery and quantitation. |
| More
Information |
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| Accurate Mass
Determination using FTICR |
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| Accurate mass
measurement has been widely accepted as a method for
confirmation of identity of substances and for identification
of the elemental composition of unknown compounds. For the
identification of unknowns it is important to get the best
mass accuracy available, because the number of possible
elemental composition increases dramatically with increased
uncertainty in the mass accuracy. Most commercially available
mass spectrometers achieve best mass accuracy (<5 ppm) only
with internal calibration. Due to complications like
ionization suppression users tend... |
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| Download Full
Article (PDF 418 kB) |
| Software:
Xcalibur™ 2.0 and XReport
1.0 |
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Version 2.0 of
Xcalibur continues the tradition of a very versatile,
easy-to-use data system - now enabling 21 CFR part 11
compliance. Whether you are an experienced Xcalibur user or
new to our software, Xcalibur's homepage offers easy
navigation through the process of instrument setup, sequence
setup, and data acquisition. The review of results is easy in
one of three browser environments; Qual Browser, Quan Browser,
Library Browser. Reporting is now easier with the all-new
XReport. |
| More
Information |
| Trap Talk: Scan Speed
vs. Cycle Time |
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| One of the key
advantages of ion trap mass spectrometry is the ability to
perform multiple MS/MS (or MSⁿ)
fragmentation steps on a single precursor ion and its product
ions to create a cascade of product-precursor ion
relationships that yield extensive amounts of structural
information. To achieve maximum benefit in an LC/MSⁿ experiment, the series of events starting
from the process of filling the ion trap through detecting the
ions must be optimized for a chromatographic timescale. |
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| Download Full
Article (PDF 116
kB) |
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