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| New Products
Introduced at ASMS 2007 |
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Thermo Fisher Scientific
introduced several new products at ASMS 2007 including:
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LTQ Orbitrap XL™ - Unrivaled Performance and Flexibility
.
LTQ Orbitrap Discovery™ - Breakthrough Technology for Every
Lab
. ETD on the LTQ XL - Improving Protein
Characterization with Ion/Ion Chemistry
. LCQ Fleet LC/MSⁿ
- Exceptional Analytical Value
. FAIMS on Ion Traps -
Multiple Degrees of Separation
. TSQ Quantum GC - The Next
Evolution in GC Triple Quadrupoles
. Quick Calc - Powering
HT-ADME Research |
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| Learn More About
These Products |
| Tip
of the Month: NSI Infusion |
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When tuning for
NSI optimization, infusion via syringe at 1uL/min can be
erratic or can occasionally leak at the syringe sleeve
fitting. Filling a 100uL loop with the tuning peptide
(utilising the syringe and sleeve to fill) and then fitting
this using adaptors between the pump line and the silica
tubing leading to the NSI needle, can help address this issue.
The pump needs to be set at 1uL/min (100uL/min, split 1:100).
The subsequent flow is very stable and tuning optimization is
more realistic.
--- Contributed by Critical Mass
Subscriber Nigel Joyce, Crop and Food Research, New
Zealand |
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| Software
Update |
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Here are the software
updates for July 2007. Note that SIEVE 1.1.0 FREE upgrade is
available only until September 30 2007. Please contact your
local sales representative regarding questions on how to
upgrade your software.
Note: This list is subject to
change without notice as our software is continuously being
updated. |
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| View Updates
Now |
| Webinar: Proteomics
Analysis - LTQ Orbitrap XL™ vs. QSTAR Elite® By Vlad
Zabrouskov, Ph.D. |
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This webinar
discusses the results of a head-to-head comparison between the
QSTAR Elite (with ProteinPilot™) and the LTQ Orbitrap XL (with
Mascot™) in identifying and structurally characterizing
peptides in a highly complex sample mixture. |
| Register to View
Webinar |
| Webinar: MetWorks
Software for the Confident Analysis of Metabolism Data By
Amber Kohl, Ph.D. |
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This webinar highlights
the details of this powerful data mining tool for small
molecules. This MetWorks webinar consists of six different
sections, including:
• an introduction to the software
•
a discussion of the user-friendly MetWorks workflow
• how
to process a sample from a Data Dependent™ experiment
• how
to acquire and process a sequence of samples
• how to
process a sample from a Quantum precursor ion or constant
neutral loss experiment, and
• coverage of the accurate
mass features that are incorporated in MetWorks.
MetWorks
continues to be a commanding means for profiling metabolic
data. Learn how this tool can ensure confident analysis of
metabolism data by viewing this 108 minute webinar. |
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| Register to View
Webinar |
| Webinar: Introduction
to the QED Scan Function for Triple Quadrupole Mass
Spectrometry By Jonathan Beck, Ph.D. |
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This webinar
discusses the features and benefits of using the Quantitative
Enhanced Data Dependent Scan function (QED) in triple
quadrupole experiments. QED enables the collection of both
qualitative full scan Q3 data and quantitative SRM data in the
same experiment. The webinar then elucidates how QED can be
applied to any workflow, from proteomics to drug metabolites
to environmental contaminants. |
| Register to View
Webinar |
| Webinar: QuickQuan™
2.0 – High-Throughput Screening (HTS) Software and Hardware
for Drug Discovery By Nick Duczak |
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| This webinar discusses
QuickQuan as a HTS solution in Drug Discovery. QuickQuan
alleviates the bottleneck of sample analysis in early drug
discovery. It is designed for mid- to high-throughput
quantification laboratories who operate in an unregulated,
non-GLP environment. QuickQuan 2.0 provides users with a
friendly and functional graphical user interface, as well as a
comprehensive Getting Started guide to assist new users in
learning the software. Attend this 28 minute webinar to learn
more. |
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| Register to View
Webinar |
| Food
Analysis: Multi-residue Analysis of Pesticides in Food using
GC/MS/MS |
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Food safety
concerns are on the rise amongst consumers worldwide. In 2006,
sweeping changes were made to the Food Hygiene Law in Japan
regarding residues of agricultural chemicals, including
pesticides, in foods. As a result, standard residue values
were established for approximately 800 pesticides. All food
items produced in or imported into Japan are required to meet
the standards established by this law. If pesticide residues
in any food items exceed these standards, then the
distribution and sale of the food is prohibited. This Positive
List System has had a significant effect not only on the
Japanese domestic production, but also on much of the food
exported to Japan from various foreign countries such as
China, the United States, and Taiwan. |
| Download Full
Article [PDF 1196 kB] |
| Congratulations to
our ASMS 2007 SMI Contest Winners! |
|
And the winners
are...
. Celeste Ptak, Cornell University
. Justin
Brumbaugh, University of Wisconsin
. Dan Knapp, Medical
University of South Carolina
The winners collected clues,
analyzed data, correctly identified the cause of death in the
race car driver mystery staged in Thermo Fisher Scientific's
hospitality suite, and were drawn from a pool of correct
entries. Thanks to all participants for being part of the
field investigation team to help solve the mystery. |
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| Did you get the
correct answer? Find Out
Now |
| Proteomics: Targeted
Quantitative Protein Analysis in Human Serum using Hi-Res.
MSRM |
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A common endpoint
for a biomarker discovery experiment is a list of putative
marker proteins. A reasonable next step is to then perform
targeted quantitative measurements of these proteins in an
expanded patient population to assess their validity as
markers. Analytical accuracy and precision are required for
unambiguous quantitative analysis of targeted proteins from
very complex mixtures. Wide dynamic range and high sensitivity
are critical for... |
| Download Full
Article [PDF 819 kB] |
| Trap Talk:
High-Precision Elemental Composition Determination of Small
Molecules using the LTQ FT Ultra Hybrid Mass
Spec. |
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| Fourier-transform ion
cyclotron resonance mass spectrometry (FTICR-MS) plays an
important role for determining exact mass measurements at
ultra-high resolution in academic and industrial service and
research labs. Achieving exact mass measurements at very high
accuracy in the parts per billion (ppb) level on precursor as
well as on product ions enables high confidence level
determination of the elemental composition as well as
unambiguous assignment of fragment ions. |
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| Download Full
Article [PDF 1189
kB] |
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