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| On-Demand Webinar:
Mass Frontier™ 5.0 Software – Accelerating the Science of
Spectral Interpretation By Alisha Roberts,
Ph.D. |
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| Mass Frontier 5.0 is a
powerful software package for the management, evaluation and
interpretation of mass spectra. This software provides a
number of useful tools for processing and organizing mass
spectral and chromatographic data. Additionally, Mass Frontier
provides rational understanding of compound structures and
mechanistic understanding of fragmentation schemes. This is a
multi-part webinar discussing the various aspects of this
software. |
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| Register Now to
View this On-Demand
Webinar |
| Proteomics: Protein
ID in Complex Digests - A Comparative Study |
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Comprehensive,
accurate identification of proteins in complex sample mixtures
is an important fundamental capability for any proteomics
research laboratory. Technology advancements in both hardware
and software continue to expand and refine our view of any
proteomic system in terms of protein identities and their
post-translational modifications (PTMs). It has been suggested
that the very recent ability to routinely obtain accurate mass
measurements (<5 ppm RMS) on precursor and MS/MS fragment
ions in proteomic experiments should lead to unprecedented
accuracy in the ability to identify and characterize
proteins. |
| Download Full
Article [1517 kB] |
| Proteomics Seminar
Series: Europe |
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| Thermo Fisher will present
a set of FREE educational one-day seminars that will highlight
new developments in mass spectrometry and sample preparation
techniques applied to proteomics research. The keynote
speakers will provide insight into progress on biomarker
discovery within the cardiovascular research community (Prof.
Peipei Ping, UCLA), discuss specific phosphorylation events
and related pathway analyses (Prof. Roman Zubarev, University
Uppsala), introduce advanced ETD techniques for
characterization of intact proteins (Dr. James Stephenson, RTI
North Carolina), and describe powerful approaches to studying
organisms with unsequenced genomes (Dr. Andrej Shevchenko, MPI
Dresden). In addition, the series will also feature several of
Thermo Fisher's research scientists and application
specialists. |
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| View Agenda and
Reserve Your Spot Now |
| Environmental
Application: Analysis of Regulated Pesticides in Drinking
Water |
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Pesticides are
used throughout the world to control pests that are harmful to
crops, animals, or people. Because of the danger of pesticides
to human health and the environment, regulatory agencies
control their use and set pesticide residue tolerance levels.
The limits of detection (LODs) for many of these substances
are at the parts per trillion (ppt) level. In order to achieve
this level of detection, offline sample pre-concentration is
often performed. However... |
| Download Full
Article [PDF 749 kB] |
| Abstracts Database
CD |
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| The latest release of this
database, now with twenty-seven hundred mass spec abstracts is
a wealth of information covering the spectrum of latest in
mass spectrometry technology and applications. Addressing the
needs of everyone from large molecule analysis to small
molecule analysis, this CD is a handy lab tool to possess. |
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| Order Your Copy
Now |
| Natural Products
Analysis: Profiling and Characterization of Polyphenol
Polymers from Cinnamon |
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Type 2 diabetes
is the most common metabolic disease worldwide. Although the
prevention and control of it remains unclear, there is strong
evidence that dietary factors play a role in the onset of this
disease. Previous studies have indicated that cinnamon may
mimic insulin effects and thus may improve glucose uptake.
Considering the complex composition of cinnamon, it is
important to be able to isolate and characterize the possible
active components in it. |
| Download Full
Article [PDF 951 kB] |
| Software
Update |
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Here are the software
updates for September 2007. Note version upgrade for LC
Devices software. Please contact your local sales
representative regarding questions on how to upgrade your
software.
Note: This list is subject to change
without notice. |
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| View Updates
Now |
| Chromatography:
Method Transfer from HPLC to U-HPLC |
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The use of sub-2
µm particles is becoming increasingly popular for applications
in either High Throughput Screening (HTS) assays or in Ultra
High Pressure Liquid Chromatography (U-HPLC). Sub-2 µm
particle packed columns offer advantages over the more
traditional columns packed with 3 and 5 µm particles through
shorter analysis times, improvements in resolving power,
sensitivity and peak capacity. When transferring methods from
HPLC to U-HPLC, several approaches can be taken, depending on
the analytical needs. |
| Download Full
Article [PDF 1798 kB] |
| Trap Talk: Use of
FAIMS to Separate Loperamide from PEG Prior to Ion Trap
Analysis |
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| It is common practice in
pharmaceutical development to conduct discovery phase
pharmacokinetic (PK) studies. In these studies, dosing
vehicles such as Tween 80, PEG 400, and methyl cellulose may
be used in high concentrations to dissolve the test compounds
in dose formulations. Subsequent qualitative study and
quantification of the test compounds must be carried out in
the presence of the dosing vehicles, which can cause
significant ion suppression and complicate full scan mass
spectra. Conventional liquid chromatography may be used to
separate the dosing vehicle, however this approach is
generally less than 100% efficient, and LC/MS analyses still
show the significant presence of polymers. |
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| Download Full
Article [PDF 157
kB] |
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