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| Announcing LCQuan™
2.5 for Bioanalysis |
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Thermo's LCQUAN
2.5 quantitative software package enables 21 CFR Part 11
compliance and includes several additional new features.It
features a bi-directional interface with Thermo's Watson LIMS
7.2.0.01 (Laboratory Information Management System) to provide
secure, digital data transfer that is tailored for
bioanalysis. LCQUAN 2.5 was exhibited at the 2005 AAPS Annual
Meeting and Exposition, Nashville, Tennessee, November
7-9. |
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more |
| Tip of the Month: Ion
Mapping Experiments |
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| An Ion Mapping experiment
is best used to get full structural characterization of
unknown molecules in complex mixtures. In such an experiment,
the user can get product ion scans on every parent ion over a
specified mass range. The experiment can also help to identify
automatically which parent ions were fragmented to yield a
specified product ion. The experiment thus "maps" one or more
parent ions by using the information from product ions scans.
The Finnigan™ LTQ™ has three distinct templates in instrument
setup, namely, total (or full scan) ion map, neutral loss ion
map and parent ion map. The results of any of the ion mapping
experiments can be viewed in the Xcalibur Qual Browser
window. |
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| Quantum Waves: Food
Residue Analysis of Pesticides using H-SRM |
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With increased
concern about food safety, the number of regulated pesticide
residues, which are being tested for in food, has increased
rapidly. In Japan, a new positive list system for monitoring
pesticide residues will take effect in 2006. Consequently, an
accurate high throughput multi-pesticide screening method
which can quantitate high number of pesticide residues during
a single analysis is required.The analytical results of 35
pesticide residues in food with the H-SRM detection method are
reported in this application note. |
| Download Full
Article [PDF 212
kB] |
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| 2006-2007 Thermo Wall
Calendar |
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| Request your free
2006-2007 Thermo wall calendar. |
| Order
Now |
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| 2006-2007 Columns and
Consumables Catalog |
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| Reserve your copy of the
2006-2007 consumables catalog. |
| Order
Now |
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| Software: The
Biomarker SIEVE - Label-Free Biomarker
Discovery |
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| The SIEVE is a software
framework designed to support the discovery of biomarkers by
facilitating the analysis of data from large-scale,
label-free, MALDI and/or LC-MS differential expression
proteomics experiments. The SIEVE enables users to analyze
data generated on a Finnigan LTQ (using a vMALDI or ESI ion
source), LTQ FT™ or LTQ Orbitrap™ according to a predefined
experimental design, typically a two-group, randomized,
controlled study or a single-group longitudinal study. The
automated software uses MS peak area ratios from aligned
chromatograms to determine which peptides differ significantly
in their expression - these peptides are then identified by
SEQUEST database searching. |
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| Download Full
Article [PDF 1.01 mB] |
| Proteomics:
Complementary Analysis of Human CSF
Proteins |
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Electrospray and
MALDI ionization are both commonly used to generate
biomolecular ions for mass spectrometry analysis. Findings
from previous studies have shown that both ionization
techniques can be complementary and, when combined, can
greatly improve proteome coverage and overall protein
identification in complex protein mixtures. This study
utilizes the combination of a nano LC-ESI/MS/MS with
concurrent LCMALDI/MS/MS on the same mass spectrometer (LTQ
linear ion trap) to evaluate the individual and complementary
values of both ionization techniques for the characterization
of simple standard protein digests and complex protein
mixtures such as human cerebrospinal fluid (CSF) and
serum. |
| Download Full
Article [PDF 412 kB] |
| Education |
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| Optimize the use of your
Thermo Chromatography and Mass Spectrometry instruments and
software. Register for a training course at one of many
locations worldwide. Click on the link provided below to
request a free 2006 Training Course Catalog. To view a
complete list of courses, please visit
www.thermo.com/education. |
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| Order
Now |
| Metabolomics
Scientific Meeting |
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Metabolomics
society presents Metabolomics 2006, the second scientific
meeting of the Metabolomics society in Boston, USA. Topics
include metabolomics technologies, metabolomics in healthcare,
lipid maps and lipidomics, plant metabolomics, databases,
structures and informatics, environmental metabolomics,
etc. |
| Learn
more |
| Trap Talk: Scan Speed
vs. Cycle Time |
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| One of the key advantages
of ion trap mass spectrometry is the ability to perform
multiple MS/MS (or MSⁿ) fragmentation steps on a single
precursor ion and its product ions to create a cascade of
product-precursor ion relationships that yield extensive
amounts of structural information. To achieve maximum benefit
in an LC/MSⁿ experiment, the series of events starting from
the process of filling the ion trap through detecting the ions
must be optimized for a chromatographic timescale. |
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| Download Full
Article [PDF 116
kB] |
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