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| Tip
of the Month: Elemental Composition
Calculator |
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Maximize the
power of your LTQ Orbitrap™ or Finnigan™ LTQ FT™ data with
Xcalibur™ 2.0 SR1’s Elemental Composition calculator
(available in April 2006). Xcalibur’s Qual Browser
automatically displays the elemental composition, theoretical
mass, RDB, and Delta values for your high resolution data.
Simply click on the Qual Browser Spectrum window with the
right mouse button and select Display Options. Go to the
Composition tab and click on the labels you would like to
display. Xcalibur’s Qual Browser will now automatically
annotate your peaks! |
| View
Example |
| Proteomics: Top-Down
FTMS Analysis of Integral Membrane Proteins |
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| Nearly one third of the
proteome is believed to consist of integral membrane proteins
of biological membrane bilayers that compartmentalize living
cells and as such have been identified as important drug
targets. Because of their unique chemical nature, these
proteins are difficult to characterize with conventional
enzymatic digestion and LC-MS/MS analyses of the subsequent
peptides. As an alternative approach, “top-down” protein
characterization... |
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| Download Full
Article [PDF 131 kB] |
| Environmental and
Food Safety Applications: Detecting Trace Level Nitrofuran
Metabolites in Crawfish Meat |
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Nitrofurans
(furazolidione, furaltadone, nitrofurazone and nitrofurantoin)
are a group of veterinary antibiotics banned in many countries
because of human health concerns. The ban has stimulated
significant interest in development of analytical methods for
detecting trace levels of these drug residues in animal
products. Due to the rapid in vivo metabolism of the
parent drugs, detection of nitrofurans in meat products relies
on determination of their corresponding tissue-bound
metabolites... |
| Download Full
Article [PDF 118 kB] |
| Quantum Waves:
QuickQuan for High-Throughput Drug
Discovery |
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| Many drug discovery
laboratories are relying on high-throughput screening assays
to accelerate the success rate of new chemical entities (NCEs)
into development. These assays are used to determine
properties such as metabolic stability, protein binding, and
solubility for NCEs at a rapid rate. This increased throughput
creates a bottleneck in sample analysis and data
interpretation for discovery laboratories. To alleviate this
bottleneck... |
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| Read Full
Article |
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| LTQ Orbitrap wins
Gold Editor's Choice Award |
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| Thermo Electron's LTQ
Orbitrap Hybrid Mass Spectrometer won the Pittcon 2006
Editor's Choice "Gold" Award. The LTQ Orbitrap features
superior performance for small molecule research, drug
discovery, proteomics, metabolite identification, and
metabolomics. The Orbitrap represents the first totally new
mass analyzer to be introduced to the market in over 20
years. |
| Read Full
Story |
| Introducing Proteome
Digest Newsletter |
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Announcing Proteome Digest
- Thermo's new Proteomics Newsletter. The newsletter will
include articles in the following areas:
- Label-Free
Biomarker Discovery Validation
- Top-Down Protein Isoform
Analysis
- High-Throughput Protein ID
- Quantitative
Proteomics
- Ultra-Sensitive PTM Characterization
-
Superior Fragmentation with PQD, ETD |
| Subscribe
Now |
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| New LTQ Orbitrap
Brochure |
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| Combining patented
Orbitrap technology with the highly successful Finnigan LTQ™
linear ion trap, Thermo's LTQ Orbitrap enables faster, more
sensitive and more reliable detection and identification of
compounds in complex mixtures... |
| Download New
Brochure [PDF 752 kB] |
| PITTCON® 2006
Technical Presentations |
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| Along with several new
product launches at PITTCON 2006, Thermo showcased its total
range of laboratory solutions, offering customers integrated
technology and services from sample preparation, to sample
analysis through to data interpretation and storage. |
| Register now to
receive Thermo's PITTCON technical presentation
CD |
| ABRF 2006 Proteomics
Technical Posters |
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Thermo presented several
posters at ABRF 2006 in the following categories:
- Protein
Quantification
- Biomarker Discovery and Validation
-
PTM Analysis
- Top-Down Protein Isoform Analysis
- LTQ
Orbitrap
- Finnigan vMALDI Ion Source |
| Download
Posters |
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| Small
Molecule Seminars - Asia/Europe/Canada |
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Register now to
attend informative sessions on compound identification and
bioanalysis. The new Finnigan LXQ and LTQ Orbitrap mass
spectrometers deliver more confident compound identification
faster, utilizing Data Dependent™ techniques and accurate mass
capabilities, respectively. The sessions will also cover two
software packages that enable small molecule quantitation:
QuickQuan for automated high-throughput discovery quantitation
and LCQUAN 2.5 that provides 21 CFR Part 11 compliance with
seamless integration to Watson LIMS. |
| Learn More and
Register Now |
| Trap Talk: New
Finnigan LXQ Linear Ion Trap Mass Spectrometer
Video |
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Learn what is True linear
ion trap performance, and how it improves analytical
throughput without sacrificing spectral quality. The latest
addition to the award-winning family of Finnigan ion trap
instruments offers:
- Fast cycle times for high-throughput
analyses
- High sensitivity for detection of multiple
analytes in complex matrices
- Confident structural
identification
- High-quality MSn characterization
-
Routine protein and peptide analysis |
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| View
Video |
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| Metabolomics
Scientific Meeting |
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| Metabolomics society
presents Metabolomics 2006, the second scientific meeting of
the Metabolomics society in Boston, USA. Topics include
metabolomics technologies, metabolomics in healthcare, lipid
maps and lipidomics, plant metabolomics, databases, structures
and informatics, environmental metabolomics, etc. |
| Learn
More |
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| CoSMoS
2006 |
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| The Conference on Small
Molecule Science addresses the latest in small molecule
science topics in a unique intimate setting. This innovative
research-style meeting promotes high-level discussions
focusing on the exchange of practical experience and ideas,
academic research and novel techniques. |
| Learn
More |
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