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| Tip
of the month: Probability-based peptide
scoring |
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SEQUEST® users
are familiar with Xcorr, ΔCn, and Sp values calculated for
peptide matches after a protein database search. They can be
used to filter results from a proteomics experiment and
identify the best peptide match for each peptide MS/MS
spectrum. A new probability-based scoring algorithm is
included in database search results from BioWorks 3.2. This
score is separate from the SEQUEST scores and thus retains the
sensitivity of SEQUEST scores while adding the more stringent
probability-based scoring for ranking the results of the
peptide matches. In addition, a new tool for creating reversed
databases, together with the new Protein Comparison view,
enables the user to compare probability values obtained with a
normal and a reversed database and establish the parameters
that give the most confidence in the results.
* SEQUEST is a registered trademark of the University
of Washington |
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| Thermo at ASMS 2006:
Booth 77 |
|
Thermo has several events
planned for ASMS 2006.
- User meeting: This
application-focused forum will take place on Sunday, May 28
beginning at 7:30 A.M. at the Westin Hotel, Grand Ballrooms 1
and 2. The meeting will feature two workshop tracks:
proteomics and small molecules.
- Annual customer
appreciation event: The customer appreciation event will
begin right after the customer forum and will feature a
behind-the-scenes tour of the Safeco field, home of the
Seattle Mariners professional baseball team.
-
Hospitality suite: The hospitality suite will be open
throughout the conference at the Westin Hotel Grand Ballroom 1
from 6:30pm until 9:30pm. |
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| Learn
more |
| Proteomics: Analysis
of complex sample of bacterial whole cell
lysate |
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Haemophilus
ducreyi is a gram-negative bacterium and a member of the
Pasteurellaceae family. It is the causative agent of the
genital ulcer disease chancroid. A detailed understanding of
the pathogenesis of chancroid is an important research
priority as chancroid has been shown to be an important
cofactor in the heterosexual transmission of HIV. The genome
of a human passage derivative H. ducreyi strain 35000 has
recently been sequenced and is now publicly available. In the
early 2000’s, the elucidation of H. ducreyi proteome was
initiated using the classical approach via 2D-gels... |
| Download full
article [1765 kB] |
| Quantum Waves:
Introducing the TSQ Quantum Access |
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| The TSQ Quantum Access is
the new benchmark triple quadrupole LC-MS/MS for Environmental
and Food Safety analysis. This system features the innovative
QED MS/MS scan mode for unmatched sensitivity and selectivity.
This new triple quadrupole mass spectrometer is designed to
meet the strict analytical requirements of Environmental and
Food Safety laboratories. Based on the proven performance of
the... |
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| Read full
article |
| Metabolomics
Scientific Meeting |
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Metabolomics
society presents Metabolomics 2006, the second scientific
meeting of the Metabolomics society in Boston, USA. Topics
include metabolomics technologies, metabolomics in healthcare,
lipid maps and lipidomics, plant metabolomics, databases,
structures and informatics, environmental metabolomics,
etc. |
| View
program |
| CoSMoS
2006 |
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| The Conference on Small
Molecule Science addresses the latest in small molecule
science topics in a unique, intimate setting. This innovative
research-style meeting promotes high-level discussions
focusing on the exchange of practical experience and ideas,
academic research and novel techniques. |
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| Learn
more |
| Thermo at IMSC 2006 -
Prague Congress Centre, Prague, Czech
Republic |
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Thermo is pleased
to present its full range of state-of-the-art instrument
systems, advanced software, and innovative column technology
at IMSC 2006. Learn more from our experts about the latest
cutting edge developments in instrumentation - ion trap,
quadrupole, hybrid, magnetic sector mass spectrometers, and
hyphenated multi-instrument combinations of
products.
Watch this space for further
information. |
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| Trap talk: Using
Multistage Activation |
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| The preferred approach for
identifying unknowns using mass spectrometry is to produce
structurally significant product ions using the process of ion
dissociation. A method commonly known as Data Dependent™
Neutral Loss MS3 (DDNLMS3) analysis enables selective
fragmentation by isolating a neutral loss ion fragment from an
MS/MS experiment and then subjecting it to further
dissociation. The production of neutral loss ions in MS/MS,
however, is almost always... |
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| Download full
article [PDF
63kB] |
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