| Thermo at IMSC 2006
Booth 6, 2nd Floor, Prague Congress Center |
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Thermo is pleased
to present its full range of state-of-the-art instrument
systems, advanced software, and innovative column technology
at IMSC 2006. Featured products cover applications in
Proteomics, Quantitation and Metabolism. Learn more from our
experts about the latest cutting edge developments in
instrumentation - ion trap, quadrupole, hybrid, magnetic
sector mass spectrometers, and hyphenated multi-instrument
combinations of products. The user meeting will feature
several talks covering biomarkers, proteomics, metabolomics,
FAIMS, environmental and food safety analysis and more. The
workshops feature metabolite identification with the help of
spectral trees, quantitation with FAIMS and ETD in
proteomics. |
| Learn More and
Register Now |
| Tip of the Month: LTQ
2.0 and INTAMS |
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| Xcalibur 2.0/LTQ 2.0 now
offers support for Independent Time-Bound Non-Data Dependent
MS/MS Precursor Mass Windows (INTAMS). MS/MS precursor masses
can be defined independent of method segments and referenced
from a single scan event definition in the instrument setup
page. Each mass entry has its own start and end time. Separate
MS/MS precursor tables can be defined for positive and
negative polarity modes. Up to 20,000 MS/MS precursor masses
can be assigned to each polarity table. |
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| See
How |
| Essential Lipidomics
using the LTQ Orbitrap |
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Lipids are
exceptionally diverse in their structural, chemical, and
physical properties. A large number of lipids of various
classes are present in cell membranes. That said, the
compositional differences between various membranes, membrane
compartments, and microdomains are quantitative, rather than
qualitative. The LTQ Orbitrap coupled to automated nanoflow
chip-based electrospray ionization source, is a versatile tool
applicable to lipid analysis. This article covers 3 important
areas of study in lipidomics, namely, quantitation of isomeric
phosphatidylcholines, resolving isobaric species and
compositional assignment and fragmentation pathways. |
| Download Full
Article [PDF 422 kB] |
| Analysis of Labile
Gangliosides using vMALDI |
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| Gangliosides are molecules
found on the plasma membranes of many types of cells in the
body, with particular abundance in the central nervous system.
They play important biological roles such as toxin receptors
and with cell-to-cell recognition in adhesion. Their growth is
also up-regulated in cancerous cells and therefore could be
targeted as important molecules for cancer research. The
composition of gangliosides is dependent on species as well as
cell type and can also change according to disease or
developmental states and therefore may be regarded as
biomarkers. Current techniques to elucidate these differences
include thin layer chromatography as well as immunochemical
and immunohistochemical methods. Mass spectrometry approaches
enable “high quality... |
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| Download Full
Article [PDF 658 kB] |
| Request your ASMS
Posters and Presentations CD |
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This information
packed CD contains Thermo's posters and presentations from
ASMS 2006 covering topics involving metabolism, quantitation
and proteomics. Learn more about the latest techniques in mass
spectrometry and chromatography including FAIMS, ETD and new
application-specific software. |
| Order
Now |
| Ultra High Pressure
Liquid Chromatography |
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| The aim of a
chromatographic separation is to obtain good resolution in a
short analysis time, i.e., resolution needs to be maximized
while minimizing analysis time. Sub 2 µm particles have been
developed as a chromatographic media to achieve high
resolution of the sample components, fast analyses and high
sensitivity. Resolution (Rs) is proportional to the square
root of separation efficiency (N), as described by... |
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| Download Full
Article [PDF 113 kB] |
| Trap
Talk: Pulsed Q Collision Induced Dissociation
(PQD) |
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Among a variety
of approaches for precursor ion activation and dissociation in
ion trap mass spectrometers, resonance excitation collision
induced dissociation (CID) has been the most widely used.
Recently, a new dissociation technique called Pulsed Q
Collision Induced Dissociation (PQD), has been developed by
Thermo Electron and implemented exclusively for their linear
ion trap mass spectrometers. The patented technique of PQD
generates spectra... |
| Download Full
Article [PDF 88
kB] |
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