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Life Sciences Mass Spectrometry
| Tip of the Month: Thermo Scientific Knowledge Base for Mass Spectrometry & Chromatography |
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The Thermo Scientific Knowledge Base is a comprehensive online technical support knowledge base that places information at your fingertips twenty-four hours a day, seven days a week. The knowledge base includes searchable troubleshooting tips, problem resolution guidelines, application notes, technical documents, downloads, and parts information for Thermo Scientific Chromatography and Mass Spectrometry products.
» Visit the Thermo Scientific Knowledge Base Now!
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Special Promotions
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USA Economic Stimulus Savings*
Thermo Fisher Scientific is offering great savings on a wide range of leading Thermo Scientific instruments and services for a limited time.
» Calculate Your Savings Today!
*OFFER VALID IN THE UNITED STATES ONLY
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Trade Up to the Power of Linear Ion Trap Technology
Trade in any single quadrupole or ion trap mass spectrometer (regardless of model or manufacturer) and receive a free ETD upgrade with OR up to 30% off the price of a new linear ion trap mass spectrometer purchase. Don't miss out on this limited time promotional trade-in offer to improve the analytical capabilities of your laboratory with a new Thermo Scientific LTQ XL or LTQ Velos ion trap.
Why trade up?
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Experience superior speed and sensitivity
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Extend performance further with an upgrade path to the Thermo Scientific LTQ Orbitrap series
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Generate data faster, with more confident data interpretation from new application-specific software
» Request More Information Now
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| Proteomics: A Robust and Sensitive Workflow for Label-Free, Quantitative Identification of Differentially Expressed, Endogenous Peptides in Human Serum |
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Unbiased biomarker discovery workflows for plasma and serum have mostly focused on the identification of differentially expressed candidate proteins and their Tryptic peptides. This "shotgun approach" is severely limited by the dynamic range and diversity of proteins in blood. To ameliorate this problem, many protocols require the "depletion" of abundant proteins such as albumin and others by various affinity methods. A major caveat is that endogenous (non-tryptic) peptides are typically tightly bound to albumin and other high abundance "carrier proteins" in vivo, and are therefore lost in the depleted sample. Endogenous peptides are likely candidate biomarkers for many diseases and pathologies as they are secreted from tissues and enter the bloodstream. This phenomenon may explain why there has been little success in biomarker discovery using most shotgun methods.
This application note describes the development of a workflow specifically geared toward the efficient recovery and identification of endogenous peptides from blood utilizing a combination of up-front batch sample preparation and online liquid chromatography coupled with high-resolution tandem Mass Spectrometry using Higher Energy Collisional Dissociation (HCD) and Charge Injection Device (CID) fragmentation on a Thermo Scientific LTQ Orbitrap XL.
» Download Complete Application Note [PDF 1.08 MB]
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| Clinical Research: Plasma-free Metanephrine and Normetanephrine Quantitation Using Online Sample Extraction Coupled with Tandem Mass Spectrometry |
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Metanephrine (MN) and normetanephrine (NMN) are created by the action of catechol-O-methyl transferase on epinephrine and norepinephrine, respectively. Current clinical research methods usually involve labor-intensive, time-consuming offline sample preparation. In this study, a sensitive, selective LC-MS/MS method was developed using the Thermo Scientific Aria TLX-1 system powered by TurboFlow™ technology for online sample extraction coupled with the Thermo Scientific TSQ Vantage triple quadrupole mass spectrometer.
» Register to Download Full Application Note [PDF 294 kB]
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Sports Doping: Case Study - Analysis of Equine Doping Using TurboFlow Technology and Multiplexing with LC-MS/MS
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Screening for performance-enhancing drugs in horses is an incredibly challenging problem because race officials are usually looking for illegal steroids that have similar molecular structure as naturally occurring steroids in animals. Further complicating the testing process is the fact that horse urine and blood are both complex, dirty matrices - making the separation especially challenging.
Dr. Shawn Stanley, Chief Analyst, Singapore Turf Club, previously used a mass spectrometry system that required liquid-liquid extraction, but determined that he needed a system that was both faster and more reliable. Dr. Stanley adopted the Thermo Scientific Transcend TLX-4 system - the only truly independent, parallel, multichannel U-HPLC system.
» Register to Download Full Case Study [PDF 531 kB]
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| 18th IMSC 2009 (August 30 - September 4, Bremen, Germany) |
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Join Thermo Scientific at the 18th IMSC 2009 in Bremen, Germany to find out about new methods and instrumentation for resolving complexity in your mass spectrometry analyses.
Participation in all Thermo Scientific events is free of charge. However, capacity is limited, therefore please pre-register your interests.
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Thermo Scientific Users' Day
Sunday, August 30, 2009, 10:30 - 15:30 h
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Lunchtime Workshops
Monday, Tuesday, Wednesday, August 31, September 1 and 2, 2009
12:15 - 13:45 h
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Hospitality Suites
Monday and Tuesday, August 31 and September 1, 2009
18:15 - 21:00 h
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Thermo Fisher Scientific Job Opportunities
Thursday, September 3, 2009
» Learn more and Register
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| Upcoming Events |
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Resolving Complexity
Visit the Thermo Scientific booths for more information about products and workflows to meet your challenges.
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Europe
» 11th International Congress on Amino Acids, Peptides and Proteins, August 3-7, 2009, Vienna, Austria [Proteomics]
» TIAFT 2009, August 23-27, 2009, Geneva, Switzerland [Forensic Toxicology]
» 18th IMSC 2009, August 30 - September 4, 2009, Bremen, Germany [Mass Spectrometry]
North America
» CoSMoS 2009, August 3-5, 2009, Boston, MA, USA [Small Molecule]
» ACS Fall, August 16-18, 2009, Washington, DC, USA [General Chemistry]
» Mass Spec 2009, September 15-18, 2009, Philadelphia, PA, USA [Mass Spectrometry]
» HUPO 8th Annual World Congress, September 26-30, 2009, Toronto, Canada [Proteomics]
Asia Pacific
» Dioxin 2009, August 23-28, 2009, Beijing, China [Environmental & Food Safety]
» JAIMA, September 1-4, 2009, Tokyo, Japan
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Chromatography & Mass Spectrometry: Thermo Scientific Application Notebook
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A free 30-page Thermo Scientific Application Notebook featuring collected application notes for GC, GC-MS, LC, LC-MS and ICP-MS is now available for download! Application focus includes: environmental and food safety, clinical research/toxicology, drug discovery, metabolism/metabolomics and proteomics.
» Download Complete Application Notebook [PDF 2.94 MB]
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| Environmental: Analysis of Chloroacetanilide and Other Acetamide Herbicide Degradates in Drinking Water by LC-MS/MS |
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Chloroacetanilide herbicide compounds in drinking water, specifically ethanesulfonic acid (ESA) and oxanillic acid (OA) degradates, may be found in water supplies near agricultural production areas and are used on various crops including corn and soybeans. Therefore, monitoring of these compounds is of interest to various regulatory agencies around the world. This application note discusses a new method using LC-MS/MS with no offline sample preparation required.
» Register to Download Full Application Note [PDF 245 kB]
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Columns: Thermo Scientific Hypercarb Columns Application Notebook
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Celebrating 20 years since the introduction of Hypercarb, this applications compendium details many diverse application notes and separations that have been made possible through the use of this unique stationary phase.
» Download Complete Application Notebook [PDF 3.64 MB]
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| Trap Talk: Poster - Implementation of a Progressively Spaced Stacked Ring Ion Guide on a Linear Ion Trap Mass Spectrometer |
| Stacked ring ion guides were introduced in the early 1970s by Bahr, Gerlich, and Teloy to confine ions with radio frequency electric fields. Later, these guides were implemented in LC-MS instruments as an approach to more efficiently transmit ions at high pressure. The best known example is the so called ion funnel, in which tapered apertures provide focusing.
Recently Thermo Fisher Scientific introduced a novel implementation of the stacked ring ion guide (“S-lens”) which uses progressively spaced electrodes to more efficiently confine and focus ions with radio frequency electric fields through the high pressure region of a triple quadrupole mass spectrometer. The S-lens device has now been coupled to a linear ion trap and various performance aspects have been evaluated. This poster demonstrates the successful integration of the progressively spaced stacked ring ion guide with a linear ion trap instrument.
» Download Poster [PDF 116 kB]
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