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| Dr. Alexander Makarov
Receives 2008 ASMS Distinguished Contribution in Mass
Spectrometry Award |
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| Dr. Alexander Makarov,
Thermo Fisher Scientific's Director of Global Research for
Life Sciences Mass Spectrometry, received the 2008
Distinguished Contribution in Mass Spectrometry Award from the
American Society for Mass Spectrometry (ASMS). Dr. Makarov,
who has authored more than 30 papers and holds four patents,
received the award for his pioneering development of the
Orbitrap™ mass spectrometer. The Orbitrap analyzer has
succeeded in making high performance research analytical power
routine. This has enabled ultra-high resolution mass
spectrometry to be used to solve complex analytical problems
such as those found in pesticide analysis and drug
discovery. |
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| Read Award
Announcement on the ASMS
Website |
| TSQ
Vantage™ Triple Stage Quadrupole -- Highest Sensitivity,
Lowest Noise |
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Crafted with
Generation Two (G2) ion optics that transmits more ions
without the noise, the Thermo Scientific TSQ Vantage triple
stage quadrupole provides breakthrough performance by
delivering the highest precision at the lowest levels of
quantitation. Inspired innovation in ion source technology –
specifically aimed at handling thousands of matrix-intensive
samples – enables industry leading robustness without
compromising sensitivity. Whether the need is in analyzing
small molecules or biomolecules, the TSQ Vantage delivers
precise, consistent, and reproducible results at amazingly low
levels of quantitation.
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| Learn
More |
| The Exactive™
High-Performance Benchtop LC-MS |
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Now there’s an altogether
superior way to identify LC-MS samples – the Thermo Scientific
Exactive system. Powered by Orbitrap technology, Exactive is
an easy-to-use benchtop system combining premium performance
with a simple, intuitive interface, resulting in an LC-MS
system that’s smaller, faster as well as affordable for
virtually any lab. Exactive is ideal for solving the most
demanding analytical challenges, including complex samples
containing pesticides, metabolites or other target compounds.
Whatever your application or budget, step up to Exactive and
watch productivity soar.
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| ASMS
2008 New Products, Posters and Presentations
CD |
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This
resource-packed CD includes posters, technical presentations,
workshop presentations and information on all Thermo
Scientific products featured at ASMS. It spotlights new
products including the Exactive, Proteome Discoverer, TSQ
Vantage, MetWorks 1.2 and Mass Frontier 6.0. For access to the
complete overview of products, posters and presentations order
your ASMS 2008 CD today. |
| Order Your ASMS
2008 CD Now |
| Fossilomics Research
Enabled by Mass Spectrometry |
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| Fossilomics is the
analysis of amino acid sequences, post-translational
modifications and phylogeny of fossil bone proteins from
extinct organisms. Fossilomics has given credibility to the
theory that dinosaurs' closest living relatives are modern-day
birds. Molecular analysis of a shred of 68-million-year-old
Tyrannosaurus rex protein, along with that of 21 modern
species, confirms that dinosaurs share common ancestry with
chickens, ostriches, and to a lesser extent, alligators. Mass
spectrometers, specifically the Thermo Scientific LTQ XL and
LTQ Orbitrap were utilized in this breakthrough fossilomics
studies. |
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| Learn
More |
| Proteome Discoverer
for Proteomics |
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Proteome
Discoverer is workflow-based, proteomics data processing
software package for in-depth data mining of complex LC-MSn
data sets. The field of proteomics continues to expand and
with it the need for more advanced and flexible software tools
to interpret the data. Proteome Discoverer is the latest
comprehensive proteomics software solution from Thermo Fisher
Scientific and was designed to address the need for
flexibility by offering a wide array of bio-software tools and
customizable workflows for every proteomics experiment using
an easy-to-use, wizard-driven interface.
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| Learn
More |
| MetWorks™ 1.2
Automated Metabolite Identification
Software |
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| The MetWorks software
application integrates acquisition, processing and reporting
for metabolic LC-MSn analyses. The new interactive graphical
user interface (GUI) maximizes the power of Multiple Mass
Defect Filters™. It simplifies and accelerates the quest to
identify both expected and unexpected biotransformations. |
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| Learn
More |
| Mass
Frontier™ 6.0 Mass Spectral Interpretation |
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Newly enhanced
features in the Mass Frontier software application offer fast,
confident structural identification from nominal and
high-resolution accurate mass MSn data analysis and true
client-server database capabilities for dynamic library
searching and storage. Mass Frontier provides the tools
required to transform mass spectral data into results – fast!
The new Mass Frontier excels at predictive fragmentation and
data management. The literature-based Fragmentation Library is
now over 100,000 entries, over four times larger, for
significant improvements in the predictive capabilities. |
| Learn
More |
| Tissue Imaging Mass
Spectrometry |
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| Irinotecan, isolated from
the Chinese tree Camptotheca acuminata, has shown strong
antitumor activity against a wide variety of human solid tumor
xenografts in mice. Irinotecan is a DNA topoisomerase I
inhibitor that binds to and prevents dissociation of the
DNA-topoisomerase I complex (involved in DNA replication),
thereby inhibiting enzyme activity. Lack of microvessels has
been shown to offer resistance to irinotecan therapy in human
head and squamous carcinomas. This application note describes
the method used to determine irinotecan metabolites and their
distribution in human tumors directly from tissue by MALDI LTQ
XL Imaging MS. |
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| Download Full
Article [PDF 606 kB] |
| LIFECYCLE Education
Services: Scientific Instrument Training |
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Gain a
competitive edge in the lab! Thermo Fisher Scientific's mass
spectrometer courses provide end users with both theoretical
and practical training on your instrument in a small classroom
environment conducive to learning. Call 1-800-532-4752 or
visit the website to find out more about our breadth of mass
spec courses. |
| Learn
More |
| Trap Talk: Using
Multiple Mass Defect Filters and Higher Energy Collisional
Dissociation on an LTQ Orbitrap XL |
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| An integral part of drug
discovery and development is the identification of drug
metabolites formed through phase I and phase II metabolic
reactions. These metabolites may have either intrinsic
pharmacological activity or display specific toxicity. LC-MS
has become the cornerstone in drug metabolite identification
because of its sensitivity and ability to analyze complex
mixtures. In particular, LC-MSn employing linear ion trap
(LIT) technology has become widely used because of its speed,
sensitivity and robustness in generating rich structure
information. |
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| Download Full
Article [PDF 459
kB] |
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