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| Tip
of the Month: Library of Compounds |
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Did you know that
there is a library of over 1000 compounds included on every
TSQ Quantum system? Some of the spectra include pesticides and
antibiotic compounds, all generated on the TSQ Quantum series
of instruments. To find out more, ask your sales
representative for details. |
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| Webinar:
Understanding Ion Suppression by Rohan A. Thakur,
Ph.D. |
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| This webinar reviews some
of the reasons behind electrospray-based ion suppression and
ways to avoid it. The electrospray technique is reviewed, and
conclusions from three key peer reviewed publications that
correlate the impact of residual matrix components to ion
suppression are highlighted. According to the literature,
increased sample preparation techniques and better
chromatography can decrease matrix effects. With this in mind,
TurboFlow technology and its impact on ion suppression is
studied using several examples. TurboFlow methods offer a
unique way to reduce ion suppression, employing size
exclusion, column chemistry, and gradient techniques that
avoid phospholipid co-elution. The webinar concludes with tips
on how to avoid ion suppression in LC-MS/MS. |
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| Register to View
Webinar Now |
| Proteomics: Efficient
Data Pre-processing of Unit Resolution ETD MS/MS
Spectra |
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Confident
assignment of the charge state of a precursor ion from which a
particular MS/MS spectrum is derived is crucial for successful
and efficient spectrum analysis. High quality spectra obtained
by Electron Transfer Dissociation (ETD) are usually observed
from peptide precursors with charge states 3+ and higher. In
the absence of precursor ion charge state information from
unit resolution full MS spectra, several charge states
are... |
| Download Full
Article [PDF 376 kB] |
| HUPO 2007
Posters |
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Several posters were
presented at HUPO's 6th Annual World Congress in 2007,
covering these application areas:
- Targeted protein
analysis using the TSQ Quantum Ultra™ for high-throughput
peptide/protein quantitation
- Ground-breaking Electron
Transfer Dissociation (ETD) technology for increased protein
coverage, phosphopeptide analysis and glycopeptide
characterization
- LTQ Orbitrap XL™ for definitive iTRAQ™
quantitation
- SIEVE™ automated software for biomarker
discovery
- HEAVYPeptide AQUA internal standards for
absolute protein quantitation
- SILAC™ reagent kits for
quantitative analysis of differential protein expression |
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| Download
Posters |
| Webinar: The Complete
Bioanalysis Solution for Regulated Environments By Patrick
Jeanville, Ph.D. |
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This webinar
discusses LCquan software, a complete solution for
quantitative bioanalysis in GLP environments. LCquan is a
secure data quantitation package that supports FDA regulation
21 CFR Part 11. From within a single, user-friendly GUI,
LCquan provides all the tools needed to perform quantitation
tasks, including importing sequence information from external
systems, acquiring data, developing processing methods,
reviewing and processing data, generating reports, and
exporting results to external systems. |
| Register to View
Webinar Now |
| Clinical Research and
Toxicology Resource Kit |
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| Find out how LC-MS/MS
technology can meet the most rigorous testing requirements and
reduce costs in your lab. This informational kit highlights a
wide range of advanced Thermo Scientific LC-MS/MS solutions
for clinical research and toxicology, with peer-reviewed
article reprints, application notes and brochures included. |
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| Order your
Resource Kit Now |
| FAIMS-based LC/MS
Analytical Method is Validated by A&M Labor fuer Analytik
to Ensure Human Safety in Drug Development |
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Researchers in
Germany’s A&M Labs have validated a method that uses
innovative Thermo Scientific high-Field Asymmetric Waveform
Ion Mobility Spectrometry (FAIMS) technology to remove
interferences from a drug analysis. Using this method, the
researchers can adhere to the guidelines of the FDA to ensure
human safety in drug development. Unforeseen analyte
interferences can cause validated LC-MS methods to fail,
resulting in costly delays in obtaining data from clinical
trials. |
| Read Full
Article |
| Webinar: QuickCalc
Powered by GMSU™ By Jim Koers |
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| QuickCalc powered by GMSU
is the software that removes the bottleneck of data processing
for your high throughput laboratory. Much time and effort has
been spent over the past decade developing tools to increase
sample throughput for analytical laboratories. The bottleneck
has shifted downstream to processing the massive amounts of
data generated from the instruments. QuickCalc allows the user
to complete the data cycle by not only generating integrated
areas and reports, but to also perform the actual PK,
metabolic stability and other calculations. This presentation
will introduce you to the software workflow and help you to
visualize how it will fit into your laboratory's data flow. |
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| Register to View
Webinar Now |
| Software
Update |
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Here are the
software updates for December 2007. Please contact your local
sales representative regarding questions on how to upgrade
your software. Note: This list is subject to change without
notice as our software is continuously being updated. |
| View Software
Updates |
| Environmental:
Analysis of Chloroacetanilide and Other Acetamide Herbicide
Degradates In Drinking Water (EPA Method 535) by
LC-MS/MS |
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| EPA method 535 outlines a
technique for the analysis of the fate of chloroacetanilide
herbicide compounds in drinking water, specifically
ethanesulfonic acid (ESA) and oxanillic acid (OA) degradates.
These compounds may be found in water supplies near
agricultural production areas and are used on various crops
including corn and soybeans. Therefore, regulatory agencies
around the world are interested in monitoring of these
compounds. |
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| Download Full
Article [PDF 192 kB] |
| Manual and Software
Download |
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Customers can now
download various manuals and software drivers from the Thermo
Fisher Scientific website. For information on specific
products, please contact your sales representative. |
| Visit the Manual
and Software Download
Site |
| Trap Talk: Webinar -
Tips for Successful Mass Calibration of LTQ Orbitrap™ by
Michaela Scigelova, Ph.D., and Wolfgang Metelmann-Strupat,
Ph.D. |
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| This webinar gives a
step-by-step guide to the LTQ Orbitrap mass calibration
procedures. Both normal and high mass range calibrations are
discussed. The presentation also features a special section
describing the use of a lock-mass (internal calibration). |
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| Register to View
Webinar Now |
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