THE BENEFIT OF MORE SIGNAL AND LESS NOISE
The direct benefit of more signal is better assay precision and accuracy. Combined with a robust new ion source, second generation (G2) ion optics and hyperbolic quadrupoles, the Thermo Scientific TSQ Vantage™ delivers the highest sensitivity with the lowest chemical noise.
The significant improvement in quantitative performance is shown for 10pg/mL of Alprazolam injected on Thermo Scientific Hypersil GOLD™ C-18 column (2.1x50mm, 3μm), using an isocratic solvent mixture of Acetonitrile:Water (0.1% formic acid, 65:35, v/v), at a flow rate of 400uL/min on the TSQ Vantage.
A NEW DIMENSION IN ION SOURCE ROBUSTNESS
The S-Lens captures the expanding ion-rich gas plume and efficiently focuses the ions in a tight beam into the high vacuum region. Extraneous solvent-laden gas is proficiently pumped out from between the stacked rings before it has a chance to enter the first RF-only multipole, ensuring the system remains significantly cleaner than designs not using this technology.
The S-Lens design is a significant advance over high pressure skimmer-based ion source designs as it eliminates mass discrimination, and lowers the gas load on the expensive turbo-molecular pumps in the high vacuum stages. This innovation keeps the ion optical path cleaner, longer, while maintaining sensitivity.
ROBUST REPRODUCIBILITY
The TSQ Vantage meets the rigorous demands of supporting validated methods required for GLP. Whether you are analyzing small molecules or biomolecules, the TSQ Vantage gives you consistent, specific and reproducible results at amazingly low levels of quantitation.
To illustrate robustness and reproducibility for high sensitivity bioanalysis, five standard curves are overlaid on top of each other over a five-day period. Despite repeated exposure to protein precipitated rat plasma (over 1000 samples), the analysis of paroxetine could be successfully performed with unwavering precision, excellent linearity, and exceptional reproducibility.
BENEFITS OF WORKING WITHIN A SECURE DIGITAL DATA DOMAIN
With a complete focus on future developments of the world’s most advanced quantitative LC-MS/MS system comprising of LCQUAN and Watson LIMS, Thermo Fisher is committed to providing you with everything you need to be confident in the quality, security and efficiency of your GLP studies.
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